@Article{096504016X14666990347392,
AUTHOR = {Shengchao Zhang, Jun Yuan, Ruheng Zheng},
TITLE = {Suppression of Ubiquitin-Specific Peptidase 17 (USP17) Inhibits  Tumorigenesis and Invasion in Non-Small Cell Lung Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {4},
PAGES = {263--269},
URL = {http://www.techscience.com/or/v24n4/56974},
ISSN = {1555-3906},
ABSTRACT = {Recently, deubiquitinating enzymes (DUBs) are emerging as new regulators in cancer progression. However, understanding of the involvement of DUBs in non-small cell lung cancer (NSCLC) is just beginning. In this study, we 
investigated the expression and biological function of ubiquitin-specific peptidase 17 (USP17) in NSCLC progression in vitro and in vivo. We found that the expression of USP17 was higher than in a normal control. We further 
efficiently depleted USP17 expression in two different NSCLC cells, A549 and H1299. The anchorage-independent 
growth ability of these cells, estimated by soft agar colony formation assay, was significantly reduced after USP17 
knockdown. Moreover, Matrigel–Transwell analysis showed that suppression of USP17 decreased cell migration 
and invasion capacity. Molecular mechanism studies found that USP17 silencing downregulated the expression 
of matrix metalloproteases (MMP3 and MMP9) in NSCLC cells. Furthermore, animal model results showed that 
USP17 suppression inhibited NSCLC tumorigenesis and growth. Altogether, this study illustrates the important 
functions of USP17 in NSCLC and suggests that USP17 might be an attractive target for NSCLC therapy.},
DOI = {10.3727/096504016X14666990347392}
}