@Article{096504016X14666990347590,
AUTHOR = {Liu Feng, Wang Wei, Zhang Heng, Han Yantao, Wang Chunbo},
TITLE = {Knockdown of REV7 Inhibits Breast Cancer Cell Migration and Invasion},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {5},
PAGES = {315--325},
URL = {http://www.techscience.com/or/v24n5/56980},
ISSN = {1555-3906},
ABSTRACT = {REV7 (also known as MAD2L2) is a multifunctional protein involved in DNA damage tolerance, cell cycle 
regulation, gene expression, and carcinogenesis. Although its expression is reportedly associated with poor 
prognosis in several kinds of human cancers, the significance of REV7 expression in breast malignancies 
is unclear. In this study, REV7 was found to be increased in breast cancer. We found that knockdown of 
REV7 inhibited the migration, invasion, and epithelial–mesenchymal transition (EMT) of breast cancer cells. 
Meanwhile, overexpression of REV7 promoted the migration, invasion, and EMT of breast cancer cells. As 
shown by Western blot, knockdown of REV7 can promote TGF-β1 expression. Western blot analysis indicated that TGF-β1 may play a role as a downstream factor of REV7. Moreover, interference of TGF-β1 can 
also inhibit the cell’s ability for migration, invasion, and EMT, as well as in a cell line whose REV7 is overexpressed. Taken together, these results contributed to a recognition of the oncogene functions of REV7 in 
breast cancer cells and provided a novel direction to treat breast cancer.},
DOI = {10.3727/096504016X14666990347590}
}