@Article{096504016X14685034103392,
AUTHOR = {Feng Jiang, Yan Shi, Hong Lu, Guojun Li},
TITLE = {Armadillo Repeat-Containing Protein 8 (ARMC8) Silencing Inhibits  Proliferation and Invasion in Osteosarcoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {5},
PAGES = {381--389},
URL = {http://www.techscience.com/or/v24n5/56987},
ISSN = {1555-3906},
ABSTRACT = {Armadillo repeat-containing protein 8 (ARMC8) plays an important role in regulating cell migration, proliferation, tissue maintenance, signal transduction, and tumorigenesis. However, the expression pattern and role of 
ARMC8 in osteosarcoma are still unclear. In this study, our aims were to examine the effects of ARMC8 on 
osteosarcoma and to explore its underlying mechanism. Our results demonstrated that ARMC8 was overexpressed 
in osteosarcoma cell lines. Knockdown of ARMC8 significantly inhibited osteosarcoma cell proliferation in vitro 
and markedly inhibited xenograft tumor growth in vivo. ARMC8 silencing also suppressed the epithelial–
mesenchymal transition (EMT) phenotype, as well as inhibited the migration and invasion of osteosarcoma cells. 
Furthermore, knockdown of ARMC8 obviously inhibited the expression of β-catenin, c-Myc, and cyclin D1 in 
MG-63 cells. In conclusion, this report demonstrates that ARMC8 silencing inhibits proliferation and invasion of 
osteosarcoma cells. Therefore, ARMC8 may play an important role in the development and progression of human 
osteosarcoma and may represent a novel therapeutic target in the treatment of osteosarcoma.},
DOI = {10.3727/096504016X14685034103392}
}