@Article{096504016X14685034103239,
AUTHOR = {Dayong Yan, Xiaoqing Cai, Yu Feng},
TITLE = {miR-183 Modulates Cell Apoptosis and Proliferation  in Tongue Squamous Cell Carcinoma SCC25 Cell Line},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {6},
PAGES = {399--404},
URL = {http://www.techscience.com/or/v24n6/56989},
ISSN = {1555-3906},
ABSTRACT = {This study was designed to investigate the role of miR-183 in modulating cell growth and apoptosis of tongue 
squamous cell carcinoma SCC25 cell line. Human squamous epithelial cell and squamous cell carcinoma cell 
line SCC25 was used, and miR-183 was inhibited. Cell growth, colony formation, and apoptotic rate, as well 
as the expression of caspase 3 and BCL-xL, were detected. Results showed that miR-183 was significantly 
overexpressed in the SCC25 cell line when compared with normal control. The miR-183 inhibitor reduced cell 
growth and colony formation, while the apoptosis percentage was significantly increased. The expression of 
activated caspase 3 and BCL-xL was obviously up- and downregulated in siRNA-transfected cells, respectively. 
In conclusion, miR-183 contributed to cell growth and proliferation, and suppressed cell apoptosis in SCC25 
cells. Therefore, miR-183 might serve as a therapeutic target in tongue squamous cell carcinoma (TSCC).},
DOI = {10.3727/096504016X14685034103239}
}