@Article{096504016X14685034103716,
AUTHOR = {Xue-fei Jin, Hai Li, Shi Zong, Hong-yan Li},
TITLE = {Knockdown of Collagen Triple Helix Repeat Containing-1 Inhibits  the Proliferation and Epithelial-to-Mesenchymal Transition  in Renal Cell Carcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {6},
PAGES = {477--485},
URL = {http://www.techscience.com/or/v24n6/57005},
ISSN = {1555-3906},
ABSTRACT = {Collagen triple helix repeat containing-1 (CTHRC1), a secreted glycoprotein, is frequently upregulated in 
human cancers. However, the functional role of CTHRC1 in renal cell carcinoma (RCC) remains unclear. Thus, 
the aim of this study was to explore the role of CTHRC1 in RCC. Our results demonstrated that CTHRC1 was 
upregulated in RCC tissues and cell lines. Knockdown of CTHRC1 significantly inhibits the proliferation in 
RCCs. Furthermore, knockdown of CTHRC1 significantly inhibited the epithelial-to-mesenchymal transition 
(EMT) process in RCCs, as well as suppressed RCC cell migration and invasion. Mechanistically, knockdown of 
CTHRC1 inhibited the expression of β-catenin, c-Myc, and cyclin D1 in RCC cells. In conclusion, the results of 
the present study indicated that CTHRC1 downregulation inhibited proliferation, migration, EMT, and β-catenin 
expression in RCC cells. Therefore, CTHRC1 may be a potential therapeutic target for the treatment of RCC.},
DOI = {10.3727/096504016X14685034103716}
}