@Article{096504016X14719078133483,
AUTHOR = {Yanhua Li, Xia Chen, Hong Lu},
TITLE = {Knockdown of SLC34A2 Inhibits Hepatocellular Carcinoma  Cell Proliferation and Invasion},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {6},
PAGES = {511--519},
URL = {http://www.techscience.com/or/v24n6/57008},
ISSN = {1555-3906},
ABSTRACT = {The gene solute carrier family 34 (sodium phosphate), member 2 (SLC34A2), is a member of the SLC34 
family. Increasing evidence suggests that SLC34A2 is involved in the development of many human carcinomas. However, its role in hepatocellular carcinoma (HCC) is still unclear. Therefore, in this study we 
investigated the role of SLC34A2 in HCC and explored the underlying mechanism. We found that the expression of SLC34A2 is upregulated in HCC cell lines. Knockdown of SLC34A2 obviously inhibited HCC cell 
proliferation, migration/invasion, and the epithelial–mesenchymal transition (EMT) phenotype. Furthermore, 
knockdown of SLC34A2 significantly inhibited the expression of phosphorylated PI3K and AKT in HCC 
cells. Taken together, these results suggest that knockdown of SLC34A2 inhibits proliferation and migration 
by suppressing activation of the PI3K/AKT signaling pathway in HCC cells, and SLC34A2 may be a potential 
therapeutic target for the treatment of HCC.},
DOI = {10.3727/096504016X14719078133483}
}