@Article{096504016X14685034103833,
AUTHOR = {Yao Shi, Xiaoke Sun, Xiafen He},
TITLE = {Overexpression of Aristaless-Like Homeobox-4 Inhibits Proliferation,  Invasion, and EMT in Hepatocellular Carcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {1},
PAGES = {11--18},
URL = {http://www.techscience.com/or/v25n1/56777},
ISSN = {1555-3906},
ABSTRACT = {Aristaless-like homeobox-4 (ALX4), a member of the Aristaless-like homeobox family, has been found to be 
involved in tumor cell proliferation, migration, and invasion. However, the role of ALX4 in hepatocellular 
carcinoma (HCC) remains largely unclear. Therefore, in this study we investigated the effects of ALX4 on 
HCC. The study results indicated that the expression of ALX4 was downregulated in HCC tissues and cell 
lines. Furthermore, we demonstrated that overexpression of ALX4 inhibited the proliferation, invasion, and 
epithelial–mesenchymal transition (EMT) in HCC cells. We also found that ALX4 had an inhibitory effect on 
the sonic hedgehog (Shh) signaling pathway. Taken together, the results suggest that ALX4 may be a promising 
target for HCC treatment.},
DOI = {10.3727/096504016X14685034103833}
}