@Article{096504016X14719078133168,
AUTHOR = {Hongyan Ge, Di Zou, Yingshu Wang, Hao Jiang, Liping Wang},
TITLE = {MicroRNA-377 Downregulates Bcl-xL and Increases Apoptosis in  Hepatocellular Carcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {1},
PAGES = {29--34},
URL = {http://www.techscience.com/or/v25n1/56779},
ISSN = {1555-3906},
ABSTRACT = {Aberrantly expressed microRNAs (miRNAs/miRs) and their role in cancer development have recently gained 
more attention. However, the potential role of miRNAs in hepatocellular carcinoma (HCC) remains largely 
unknown. In this study, we demonstrated that miR-377 was markedly downregulated in HCC cell lines and 
primary human HCC tissues. The decreased expression of miR-377 contributes to the upregulation of Bcl-xL 
expression by targeting its 3'-untranslated region (3'-UTR). Functionally, knockdown of miR-377 noticeably 
increased HCC cell growth and colony formation and inhibited apoptosis. In contrast, overexpression of miR-377 
suppressed cell proliferation and increased apoptosis. This study provides new insights for the use of miR-377 as 
a potential molecular target in HCC therapy.},
DOI = {10.3727/096504016X14719078133168}
}