@Article{096504016X14719078133320,
AUTHOR = {Ke Wang, Yu Ren, Yang Liu, Jian Zhang, Jian-jun He},
TITLE = {Tumor Necrosis Factor (TNF)-α-Induced Protein 8-like-2 (TIPE2) Inhibits  Proliferation and Tumorigenesis in Breast Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {1},
PAGES = {55--63},
URL = {http://www.techscience.com/or/v25n1/56782},
ISSN = {1555-3906},
ABSTRACT = {Tumor necrosis factor-a (TNF-a)-induced protein 8-like-2 (TNFAIP8L2 or TIPE2), a member of the tumor 
necrosis TNFAIP8 family, was found to be involved in the development and progression of several tumors. 
However, to date, the role of TIPE2 in breast cancer is still unclear. Thus, the aim of this study is to explore 
the role of TIPE2 in breast cancer. Our results indicated that TIPE2 expression was significantly decreased 
in human breast cancer tissue and cell lines. Overexpression of TIPE2 inhibited the proliferation in vitro and 
tumor xenograft growth in vivo. TIPE2 also inhibited the migration/invasion of breast cancer cells through preventing the epithelial-to-mesenchymal transition (EMT) phenotype. Mechanically, TIPE2 inhibited the expression of b-catenin, cyclin D1, and c-Myc in breast cancer cells. In conclusion, our findings show that TIPE2 may 
play an important role in breast cancer cell proliferation, invasion, and tumorigenesis in vivo. Therefore, TIPE2 
may be a potential molecular target for the treatment of breast cancer.},
DOI = {10.3727/096504016X14719078133320}
}