@Article{096504016X14719078133447,
AUTHOR = {Minglei Zhang, Dapeng Wang, Tongtong Zhu, Ruofeng Yin},
TITLE = {RASSF4 Overexpression Inhibits the Proliferation, Invasion, EMT,  and Wnt Signaling Pathway in Osteosarcoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {1},
PAGES = {83--91},
URL = {http://www.techscience.com/or/v25n1/56785},
ISSN = {1555-3906},
ABSTRACT = {RASSF4, a member of the RASSF family, is broadly expressed in normal tissues but often inactivated in human 
cancers. Despite various studies on RASSF4, its role in osteosarcoma remains unclear. Therefore, in this study, 
we investigated the effects of RASSF4 expression on osteosarcoma cells and explored the underlying mechanism. The results of our study showed that RASSF4 was lowly expressed in osteosarcoma tissues and cells. 
RASSF4 overexpression significantly inhibited proliferation, migration, and invasion as well as the EMT process in osteosarcoma cells. Meanwhile, we found that RASSF4 overexpression markedly decreased the protein 
expression of β-catenin, cyclin D1, and c-Myc in osteosarcoma cells. In conclusion, our findings showed that 
RASSF4 overexpression inhibits proliferation, invasion, EMT, and Wnt signaling pathway in osteosarcoma 
cells. Thus, RASSF4 may be considered a novel target for osteosarcoma treatment.},
DOI = {10.3727/096504016X14719078133447}
}