@Article{096504016X14719078133564,
AUTHOR = {Shoumiao Li, Baozhong Li, Jiaxiang Wang, Da Zhang, Zhiqiang Liu, Zhizhong Zhang, Wei Zhang, Yunjie Wang, Dongxiao Bai, Jianyun Guan, Yong Zhang},
TITLE = {Identification of Sensitivity Predictors of Neoadjuvant Chemotherapy  for the Treatment of Adenocarcinoma of Gastroesophageal Junction},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {1},
PAGES = {93--97},
URL = {http://www.techscience.com/or/v25n1/56786},
ISSN = {1555-3906},
ABSTRACT = {The identification of reliable predictors of chemotherapy sensitivity and early screening of adenocarcinoma 
of gastroesophageal junction (AGEJ) patients who are resistant to chemotherapy has become an important 
area of clinical and translational research. We aimed to investigate the predictive value of seven cancerassociated cellular proteins for neoadjuvant chemotherapy in AGEJ patients. Clinical data of 93 patients who 
received neoadjuvant chemotherapy for locally advanced AGEJ between June 2010 and December 2014 were 
reviewed. All patients were administered the combination regimen of S-1 and oxaliplatin (SOX). Expression 
of P-glycoprotein (P-gp), glutathione S-transferase-p (GST-π), topoisomerase II (topo II), multidrug resistance gene-associated protein (MRP), lung resistance-related protein (LRP), Ki-67, and p53 was determined by 
immunohistochemistry (IHC) in AGEJ tissues before neoadjuvant chemotherapy. Chemotherapeutic efficacy 
was evaluated according to RECIST 1.0 standards and histopathological results, and the relationship between 
the expression of the cellular proteins and chemotherapy efficacy was analyzed. The SOX regimen was associated with an overall response rate of 46.2%. The frequency of expression of the seven cancer-associated factors 
in the AGEJ tissues was as follows: P-gp, 64.5%; GST-π, 39.8%; topo II, 72.0%; MRP, 33.3%; LRP, 68.8%; 
Ki-67, 62.4%; and p53, 40.9%. Expression of Ki-67 (<i>p</i> = 0.003) and p53 (<i>p</i> = 0.009) was significantly correlated with chemotherapy sensitivity. Elevated Ki-67 expression and decreased p53 expression predict for SOX 
insensitivity in AGEJ, and the cellular expression of these respective proteins may provide a useful reference 
for designing individualized chemotherapy regimens for AGEJ patients in the future.},
DOI = {10.3727/096504016X14719078133564}
}