@Article{096504016X14719078133609,
AUTHOR = {Xuan Liang, Qun-Li Men, Yong-wei Li, He-Cheng Li, Tie Chong, Zhao-lun Li},
TITLE = {Silencing of Armadillo Repeat-Containing Protein 8 (ARMc8) Inhibits TGF-β-Induced EMT in Bladder Carcinoma UMUC3 Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {1},
PAGES = {99--105},
URL = {http://www.techscience.com/or/v25n1/56787},
ISSN = {1555-3906},
ABSTRACT = {Armadillo repeat-containing protein 8 (ARMc8) is a key factor in regulating cell migration, proliferation, tissue maintenance, and tumorigenesis. However, its role in bladder cancer remains unknown. Thus, in this study 
we sought to investigate the effect of ARMc8 on the epithelial-to-mesenchymal transition (EMT) progress in 
bladder cancer cells induced by transforming growth factor-b1 (TGF-β1). Our results found that ARMc8 was 
highly expressed in bladder cancer cell lines. ARMc8 silencing inhibited the TGF-β1-induced migration and 
invasion and suppressed the EMT progress in bladder cancer cells. Furthermore, ARMc8 silencing inhibited 
the TGF-β1-induced expression of β-catenin, cyclin D1, and c-myc in bladder cancer cells. In conclusion, 
the present study demonstrates a novel function for ARMc8, which acts as a mediator for TGF-β1-induced 
cell migration/invasion through modulation of the Wnt/β-catenin signaling pathway in bladder cancer cells. 
This study suggests that ARMc8 may be a potential therapeutic target for the development of therapies for 
bladder cancer.},
DOI = {10.3727/096504016X14719078133609}
}