@Article{096504016X14732772150145,
AUTHOR = {Fang Wang, Zhihong Wang, Xiaoli Gu, Jinquan Cui},
TITLE = {miR-940 Upregulation Suppresses Cell Proliferation and Induces Apoptosis  by Targeting PKC-δ in Ovarian Cancer OVCAR3 Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {1},
PAGES = {107--114},
URL = {http://www.techscience.com/or/v25n1/56788},
ISSN = {1555-3906},
ABSTRACT = {Ovarian cancer remains as one of the most threatening malignancies for females in the world. This study investigated the pivotal role of miR-940 in the progression of ovarian cancer and to reveal the possible molecular 
mechanism of its action. Ovarian cancer OVCAR3 cells were transfected with the miR-940 vector, miR-940 
inhibitor, and/or small interfering RNA (siRNA) targeting PKC-d (si-PKC-δ), respectively. After transfection, 
cell viability and cell apoptosis were analyzed, as well as cell proliferation and apoptosis-related protein expression. Compared to the control, miR-940 upregulation suppressed cell viability but induced cell apoptosis. miR-
940 upregulation increased the expression of p27, Hes1, survivin, and caspase 3, but decreased the expression 
of PKC-δ. In addition, elevated cell viability induced by the miR-940 inhibitor was significantly decreased by 
knockdown of PKC-δ, and reduced cell apoptosis induced by the miR-940 inhibitor was increased by knockdown of PKC-δ. Taken together, the results of our study suggest that upregulation of miR-940 may function 
as a suppressor in the progression of ovarian cancer by inhibiting cell proliferation and inducing apoptosis by 
targeting PKC-δ. This study may provide a basis for the possible application of miR-940 in illustrating the 
molecular pathogenic mechanism of ovarian cancer.},
DOI = {10.3727/096504016X14732772150145}
}