@Article{096504017X14811155525280,
AUTHOR = {Min Zhao, Zhiying Su, Shiyang Zhang, Liangjin Zhuang, Yudi Xie, Xiaodong Li},
TITLE = {Suppressive Role of MicroRNA-148a in Cell Proliferation and Invasion in  Ovarian Cancer Through Targeting Transforming Growth Factor-β-Induced 2},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {1},
PAGES = {155--155},
URL = {http://www.techscience.com/or/v25n1/56793},
ISSN = {1555-3906},
ABSTRACT = {Ovarian cancer (OC) is one of the most common gynecological malignancies. MicroRNAs (miRs) play a crucial role in the development and progression of OC, but the underlying mechanism remains largely unclear. Our 
study investigated the regulatory role of miR-148a in OC cell proliferation and invasion. We found that miR-
148a was significantly downregulated in OC tissues compared to their matched adjacent nontumor tissues. In 
addition, its expression was also reduced in OC cell lines (SKOV3, ES-2, OVCAR, and A2780) compared to 
normal ovarian epithelial cells. Overexpression of miR-148a caused a significant decrease in OC cell proliferation and invasion, as well as reduced MMP9 protein levels. Transforming growth factor-b-induced 2 (TGFI2) 
was further identified as a target gene of miR-148a, and its protein expression was downregulated in OC cells 
after miR-148a overexpression. Restoration of TGFI2 attenuated the suppressive effects of miR-148a on OC 
cell proliferation and invasion. Moreover, we found that TGFI2 was remarkably upregulated in OC tissues 
when compared with their matched adjacent nontumor tissues, and observed a reverse correlation between 
miR-148a and TGFI2 expression in OC tissues. On the basis of these findings, we suggest that miR-148a 
inhibits OC cell proliferation and invasion partly through inhibition of TGFI2. Therefore, our study highlights 
the importance of the miR-148a/TGFI2 axis in the malignant progression of OC.},
DOI = {10.3727/096504017X14811155525280}
}