@Article{096504016X14742891049118,
AUTHOR = {Junkai Chang, Weibo Xu, Guangchao Liu, Xinyi Du, Xiaodong Li},
TITLE = {Downregulation of Rab23 in Prostate Cancer Inhibits Tumor  Growth In Vitro and In Vivo},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {2},
PAGES = {241--248},
URL = {http://www.techscience.com/or/v25n2/56803},
ISSN = {1555-3906},
ABSTRACT = {Rab23, a novel member of the Rab GTPase family, was found to be implicated in the progression of some 
human cancers. However, what role Rab23 plays in prostate cancer (PCa) remains to be illustrated. In the 
present study, we investigated the expression pattern and roles of Rab23 in PCa. The study results showed 
that Rab23 was upregulated in PCa tissues and cell lines. Moreover, downregulation of Rab23 remarkably 
suppressed the proliferation, migration, and invasion of PCa cells. In addition, downregulation of Rab23 significantly downregulated the protein expression levels of Shh and Gli1. Furthermore, we found that the Gli1 
inhibitor GANT-61 greatly enhanced the suppressive effect of Rab23 downregulation on PCa cells. In conclusion, we suggested Rab23 as a potential therapeutic target for PCa treatment.},
DOI = {10.3727/096504016X14742891049118}
}