@Article{096504016X14732503870766,
AUTHOR = {Xin Zhang, Shaowen Li, Chunli Dong, Xiuying Xie, Yunping Zhang},
TITLE = {Knockdown of Long Noncoding RNA NR_026689 Inhibits Proliferation and  Invasion and Increases Apoptosis in Ovarian Carcinoma HO-8910PM Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {2},
PAGES = {259--265},
URL = {http://www.techscience.com/or/v25n2/56805},
ISSN = {1555-3906},
ABSTRACT = {Ovarian cancer is one of the leading causes of gynecological cancer-related deaths worldwide. We investigated 
the role of a newly discovered long noncoding RNA, NR_026689, in cell proliferation, metastasis, and apoptosis 
in ovarian cancer cells. Our results showed that NR_026689 was overexpressed in both clinical ovarian cancer patients and cultured ovarian cancer cells. Knockdown of NR_026689 in HO-8910PM cells significantly 
decreased the cell proliferative rate and the ability to form colonies. Transwell assays revealed that depletion 
of NR_026689 suppressed cell migration ability by 68% and cell invasive capacity by 71% in HO-8910PM 
cells. Moreover, specific shRNAs against NR_026689 notably promoted cell apoptosis in HO-8910PM cells by 
upregulating the expression of proapoptotic proteins, including caspase 3, caspase 9, cytochrome C, and PARP. 
Our study suggests an oncogenic potential of NR_026689 in ovarian cancer and might provide novel clues for 
the diagnosis and treatment of ovarian cancer in the clinic.},
DOI = {10.3727/096504016X14732503870766}
}