@Article{096504016X14732510786564,
AUTHOR = {Qianren Xiao, Lu Huang, Zhongzu Zhang, Xiang Chen, Jiaquan Luo, Zhanmin Zhang, Shaoqing Chen, Yong Shu, Zhimin Han, Kai Cao},
TITLE = {Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells  via Suppression of Histone Deacetylase 4},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {2},
PAGES = {267--275},
URL = {http://www.techscience.com/or/v25n2/56806},
ISSN = {1555-3906},
ABSTRACT = {miRNAs play a pivotal role in the development and progression of osteosarcoma (OS). Previous studies indicated that miR-140 acts as a tumor suppressor in many cancers. However, its accurate expression and exact 
function in OS cells remain unknown. Herein, we demonstrated the lower expression of miR-140 in 40 paired 
OS tissues. Restoring miR-140 expression in OS cells had a marked effect on inhibiting cell proliferation and 
invasion, inducing cell apoptosis in vitro, and suppressing tumor growth in vivo. Moreover, a bioinformatics 
prediction indicated that the histone deacetylase 4 (<i>HDAC4</i>) is a target gene of miR-140 and is involved in 
miR-140-mediated suppressive effects. In conclusion, our findings show that miR-140 acts as a tumor suppressor in OS by targeting <i>HDAC4</i>.},
DOI = {10.3727/096504016X14732510786564}
}