@Article{096504016X14736286083065,
AUTHOR = {Bingqian Ding, Bei Cui, Ming Gao, Zhenjiang Li, Chenyang Xu, Shaokang Fan, Weiya He},
TITLE = {Knockdown of Ras-Related Protein 25 (Rab25) Inhibits the In Vitro Cytotoxicity  and In Vivo Antitumor Activity of Human Glioblastoma Multiforme Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {3},
PAGES = {331--340},
URL = {http://www.techscience.com/or/v25n3/56812},
ISSN = {1555-3906},
ABSTRACT = {Ras-related protein 25 (Rab25) is a member of the Rab family, and it has been reported to play an important role 
in tumorigenesis. However, its direct involvement in human glioblastoma multiforme (GBM) is still unclear. The 
aim of the current study was to investigate the potential role of Rab25 in the growth, proliferation, invasion, 
and migration of human GBM. Our results showed that Rab25 expression was significantly higher in human 
GBM cell lines compared with a normal astrocyte cell line. In vitro functional studies revealed that knockdown 
of Rab25 reduced cell proliferation and inhibited invasion and migration of GBM cells. In vivo experiments 
showed that knockdown of Rab25 attenuated the tumor growth in nude mice. Finally, knockdown of Rab25 
significantly inhibited the phosphorylation levels of PI3K and AKT in GBM cells. Taken together, these findings indicate that Rab25 may act as a tumor promoter in human GBM and that approaches to target Rab25 may 
provide a novel strategy to treat this disease.},
DOI = {10.3727/096504016X14736286083065}
}