@Article{096504016X14738114257367,
AUTHOR = {Guojun Wang, Yang Fu, Guanghui Liu, Yanwei Ye, Xiefu Zhang},
TITLE = {miR-218 Inhibits Proliferation, Migration, and EMT of Gastric Cancer Cells  by Targeting WASF3},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {3},
PAGES = {355--364},
URL = {http://www.techscience.com/or/v25n3/56814},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs (miRNAs) play an important role in carcinogenesis. miR-218 is one of the most known miRNAs 
and has been demonstrated to inhibit progression in gastric cancer. However, the underlying molecular mechanism is not established. In this study, qRT-PCR and Western blot indicated that miR-218 was downregulated in 
gastric cancer cell lines SGC7901 and BGC823 compared to that in normal gastric epithelial cell line GES-1. 
MTT and wound scratch assays suggested that overexpression of miR-218 markedly suppressed cell proliferation, migration, and EMT of gastric cancer cells. Furthermore, we proved that WASF3 was a direct target of 
miR-218 by luciferase reporter assay, and restoration of WASF3 expression impairs miR-218-induced inhibition 
of proliferation, migration, and EMT in gastric cancer cells SGC7901. In summary, our results demonstrated 
that miR-218 functions as one of the tumor-suppressive miRNAs and inhibits gastric cancer tumorigenesis by 
targeting WASF3. miR-218 may serve as a potential therapeutic target for the treatment of gastric cancer.},
DOI = {10.3727/096504016X14738114257367}
}