TY  - EJOU
AU  - Liu, Xiaorui 
AU  - Li, Jingjing 
AU  - Yu, Zujiang 
AU  - Li, Juan 
AU  - Sun, Ranran 
AU  - Kan, Quancheng 

TI  - miR-935 Promotes Liver Cancer Cell Proliferation  and Migration by Targeting SOX7
T2  - Oncology Research

PY  - 2017
VL  - 25
IS  - 3
SN  - 1555-3906

AB  - Hepatocellular carcinoma (HCC) is the most common cancer in the world. MicroRNAs (miRNAs) are a type 
of small noncoding RNA that can regulate the expression of target genes under physiological and pathophysiological conditions. Aberrant expression of microRNA-935 (miR-935) has been reported in cancer studies. 
However, its expression and mechanism in HCC remain unclear. In our study, we found that miR-935 was 
upregulated in liver cancer tissues and cells. Overexpression of miR-935 in liver cells promoted cell proliferation, tumorigenesis, and cell cycle progression, whereas inhibition of miR-935 reduced cell proliferation, 
tumorigenicity, and cell cycle progression. These changes in the properties of HCC cells were associated with 
upregulation of two well-known cellular G<sub>1</sub>/S transitional regulators: cyclin D1 and c-Myc. Additionally, we 
identified SOX7 as a direct target of miR-935. Overexpression of miR-935 inhibited SOX7 expression but promoted the levels of c-Myc and cyclin D1, which promotes cell proliferation and tumorigenesis; knockdown of 
miR-935 increased SOX7 level and inhibited c-Myc and cyclin D1 expression, whereas SOX7 silencing could 
promote cell proliferation, cell motility, and invasiveness in vitro. Our findings suggest that miR-935 represents 
a biomarker and a potential new target in HCC progression by suppressing SOX7 expression.
KW  - Liver cancer; MicroRNA-935 (miR-935); SOX7

DO  - 10.3727/096504016X14747300207374