@Article{096504016X14747335734344,
AUTHOR = {Erkun Guo, Hongjiang Liu, Xiaopeng Liu},
TITLE = {Overexpression of SCUBE2 Inhibits Proliferation, Migration,  and Invasion in Glioma Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {3},
PAGES = {437--444},
URL = {http://www.techscience.com/or/v25n3/56823},
ISSN = {1555-3906},
ABSTRACT = {Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the SCUBE family of 
proteins, was recently found to play an important role in cancer development. However, little is known regarding its biological function in glioma. In the present study, we investigated the effect of SCUBE2 on glioma and 
explored its relevant mechanisms. The study showed that SCUBE2 had a low expression in glioma tissue and 
cell lines. SCUBE2 overexpression inhibited glioma cell proliferation in vitro and in vivo as well as suppressed 
glioma cell migration and invasion in vitro. Furthermore, we found that the Sonic hedgehog (Shh) signaling 
pathway was involved in the inhibitory effect of SCUBE2 overexpression on glioma cells. In light of the results 
obtained from our study, SCUBE2 may be regarded as a potential therapeutic target for glioma.},
DOI = {10.3727/096504016X14747335734344}
}