@Article{096504016X14747283032017,
AUTHOR = {Jihong Sun, Jingjing Li, Weiguo Zhang, Juan Zhang, Shenjie Sun, Guiqi Li, Hengliang Song, Daguo Wan},
TITLE = {MicroRNA-509-3p Inhibits Cancer Cell Proliferation and Migration via  Upregulation of XIAP in Gastric Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {3},
PAGES = {455--461},
URL = {http://www.techscience.com/or/v25n3/56825},
ISSN = {1555-3906},
ABSTRACT = {Gastric cancer (GC) is the fourth most common cancer globally. Recently, microRNAs (miRNAs) have been 
suggested to be closely associated with tumorigenesis. Aberrant expression of miR-509-3p has been reported in 
cancer studies. However, the expression and mechanism of its function in GC remain unclear. Here we showed 
that miR-509-3p was downregulated in GC specimens, which was associated with overall survival. Functional 
investigations demonstrated that the overexpression of miR-509-3p inhibited the migration and proliferation 
of the GC cells. Additionally, we identified X-linked inhibitor of apoptosis protein (XIAP) as a direct target of 
miR-509-3p. Knockdown of XIAP significantly attenuated the ability of proliferation, migration, and invasion 
of GC cells. The data therefore suggest that miR-509-3p plays an important role in the development and progression of GC, implicating possible applications in the clinic as a biomarker and a potential new target.},
DOI = {10.3727/096504016X14747283032017}
}