TY  - EJOU
AU  - Kato, Yoshiro 
AU  - Naiki, Yoshikazu 
AU  - Komatsu, Takayuki 
AU  - Takahashi, Kazuko 
AU  - Nakamura, Jiro 
AU  - Koide, Naoki 

TI  - A Wnt Pathway Activator Induces Apoptosis and Cell Death  in Mouse Monocytic Leukemia Cells
T2  - Oncology Research

PY  - 2017
VL  - 25
IS  - 4
SN  - 1555-3906

AB  - A Wnt agonist, 2-amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl) pyrimidine, is a cellpermeable pyrimidine compound that has been shown to mimic the effect of Wnt. In this study, leukemic mouse 
cell lines, RAW 264.7 and J774.1, were incubated with the Wnt agonist. The Wnt agonist showed cell death 
in the concentration of 1–10 mM. The Wnt agonist did not show inhibition of GSK-3β activity but induced 
β-catenin accumulation in the nucleus. The Wnt agonist showed caspase-independent cell death, but no further 
involvement in cell death ER stress signaling. Here we discuss the possible mechanism of Wnt agonist-induced 
apoptotic cell death in RAW 264.7 cells.
KW  - RAW 264.7 cells; Wnt agonist; Cytotoxicity; β-Catenin; Endoplasmic reticulum (ER) stress

DO  - 10.3727/096504016X14721731148893