@Article{096504016X14755368915591,
AUTHOR = {Fuqiang Wan, Li Peng, ChaoYu Zhu, XinFa Zhang, FangWen Chen, Tao Liu},
TITLE = {Knockdown of Latent Transforming Growth Factor-β (TGF-β)-Binding  Protein 2 (LTBP2) Inhibits Invasion and Tumorigenesis  in Thyroid Carcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {4},
PAGES = {503--510},
URL = {http://www.techscience.com/or/v25n4/56831},
ISSN = {1555-3906},
ABSTRACT = {Latent transforming growth factor-b (TGF-b)-binding protein 2 (LTBP2) is one of four proteins in the LTBP 
family of proteins (LTBP1–4) and was shown to play a vital role in tumorigenesis. However, little is known 
regarding the functional role of LTBP2 in thyroid carcinoma. Therefore, the current study aimed to evaluate 
the effect of LTBP2 expression on the proliferation, invasion, and tumorigenesis in thyroid carcinoma cells 
and to explore the molecular mechanism of LTBP2 in tumor progression. Our results showed that the expression of LTBP2 is upregulated in human thyroid carcinoma and cell lines. Knockdown of LTBP2 inhibits the 
proliferation, invasion, and EMT phenotype in thyroid carcinoma cells. Furthermore, knockdown of LTBP2 
attenuates thyroid carcinoma growth in nude mice. Finally, knockdown of LTBP2 inhibits activation of the 
PI3K/Akt pathway in thyroid carcinoma cells. In summary, the present study has provided further evidence that 
knockdown of LTBP2 inhibits invasion and tumorigenesis in thyroid carcinoma cells. Our findings may help to 
further elucidate the molecular mechanisms underlying thyroid carcinoma progression and provide candidate 
targets for the prevention and treatment of thyroid carcinoma.},
DOI = {10.3727/096504016X14755368915591}
}