@Article{096504016X14756282819385,
AUTHOR = {Jianping Shi, Yi Zhang, Nuyun Jin, Yuqin Li, Shengtian Wu, Leiming Xu},
TITLE = {MicroRNA-221-3p Plays an Oncogenic Role in Gastric Carcinoma  by Inhibiting PTEN Expression},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {4},
PAGES = {523--536},
URL = {http://www.techscience.com/or/v25n4/56833},
ISSN = {1555-3906},
ABSTRACT = {Gastric carcinoma is one of the most common malignancies in men, and microRNA plays a critical role in 
regulating the signaling networks of gastric carcinoma tumorigenesis and metastasis. We first report the functional characteristics of miR-221-3p in gastric carcinoma. Quantification in gastric carcinoma cell lines and 
tumor samples reveals significantly increasing miR-221-3p expression. Moreover, a high level of miR-221-3p 
is correlated with a poor prognosis for gastric carcinoma patients. Ectopic miR-221-3p expression significantly promotes gastric carcinoma cell proliferation, invasion, and sphere formation, while silencing miR-
221-3p significantly inhibits these abilities in gastric carcinoma cells. Tests in vivo showed that miR-221-3p 
significantly promotes tumor growth in xenograft mouse models. In this study, we reveal that miR-221-3p 
targets PTEN mRNA and downregulates PTEN, which is the possible mechanism of miR-221-3p-induced 
oncogenic properties. Collectively, we reveal a critical role for miR-221-3p in gastric carcinoma development 
and progression.},
DOI = {10.3727/096504016X14756282819385}
}