@Article{096504016X14756640150695,
AUTHOR = {Yan Zhang, Gang Cao, Qing-gong Yuan, Jun-hui Li, Wen-Bin Yang},
TITLE = {Empty Spiracles Homeobox 2 (EMX2) Inhibits the Invasion  and Tumorigenesis in Colorectal Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {4},
PAGES = {537--544},
URL = {http://www.techscience.com/or/v25n4/56834},
ISSN = {1555-3906},
ABSTRACT = {Empty spiracles homeobox 2 (EMX2) is a homeodomain-containing transcription factor that plays an essential 
role in tumorigenesis. However, to the best of our knowledge, the role of EMX2 in human colorectal cancer 
(CRC) is still unclear. Thus, the aim of this study was to investigate the expression and role of EMX2 in CRC. 
Our results demonstrated that the expression of EMX2 was greatly decreased in CRC tissues and cell lines. 
Overexpression of EMX2 significantly inhibited the proliferation in vitro and CRC tumor growth in nude mice. 
In addition, EMX2 also inhibited the migration and invasion of CRC cells. Mechanically, overexpression of 
EMX2 downregulated the expression levels of β-catenin, cyclin D1, and c-Myc in CRC cells. Taken together, our 
study demonstrates that EMX2 inhibits proliferation and tumorigenesis through inactivation of the Wnt/β-catenin 
pathway in CRC cells. Therefore, EMX2 may be a potential therapeutic target for the treatment of CRC.},
DOI = {10.3727/096504016X14756640150695}
}