@Article{096504016X14758370595285,
AUTHOR = {Hongwei Tan, Jin Qi, Guanghua Chu, Zhaoyang Liu},
TITLE = {Tripartite Motif 16 Inhibits the Migration and Invasion  in Ovarian Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {4},
PAGES = {551--558},
URL = {http://www.techscience.com/or/v25n4/56836},
ISSN = {1555-3906},
ABSTRACT = {Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite motif (TRIM) 
protein family, has been shown to play a role in tumor development and progression. However, the role of 
TRIM16 in ovarian cancer has never been revealed. Thus, in this study, we investigated the roles and mechanisms of TRIM16 in ovarian cancer. Our results demonstrated that TRIM16 expression was low in ovarian 
cancer cell lines. In addition, overexpression of TRIM16 significantly inhibited the migration and invasion in 
vitro, as well as suppressed the epithelial–mesenchymal transition (EMT) phenotype in ovarian cancer cells. 
Furthermore, overexpression of TRIM16 greatly inhibited the protein expression levels of Shh, Smo, Ptc, 
Gli-1, MMP2, and MMP9 in ovarian cancer cells. Taken together, these results strongly suggest that TRIM16 
inhibits the migration and invasion via suppressing the Sonic hedgehog signaling pathway in ovarian cancer 
cells. Thus, TRIM16 may be a novel potential therapeutic target for ovarian cancer.},
DOI = {10.3727/096504016X14758370595285}
}