@Article{096504016X14761811155298,
AUTHOR = {He-Peng Cheng, Qian Liu, Yang Li, Xiao-Dong Li, Chao-Yang Zhu},
TITLE = {The Inhibitory Effect of PDIA6 Downregulation on Bladder  Cancer Cell Proliferation and Invasion},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {4},
PAGES = {587--593},
URL = {http://www.techscience.com/or/v25n4/56840},
ISSN = {1555-3906},
ABSTRACT = {Protein disulfide isomerases A6 (PDIA6) belongs to the PDI family. Recently, PDIA6 was found to have a close 
association with various cancers. However, there has been little investigation into the biological functions of 
PDIA6 in bladder cancer (BC). In this study, we explored the expression pattern and functional significance 
of PDIA6 in BC. We found that PDIA6 was overexpressed in BC tissues and cell lines. The in vitro study 
showed that PDIA6 downregulation significantly inhibited BC proliferation and invasion. In addition, the 
in vivo experiment demonstrated that PDIA6 downregulation decreased the volume, weight, and metastasis 
of tumors. Furthermore, PDIA6 downregulation reduced the protein expression of β-catenin, cyclin D1, and 
c-Myc and thus suppressed the Wnt/β-catenin signaling pathway. In conclusion, we suggest that PDIA6 could 
be targeted for the treatment of BC.},
DOI = {10.3727/096504016X14761811155298}
}