@Article{096504016X14771034190471,
AUTHOR = {Sheng-Qiang Lu, Yan Qiu, Wei-Jie Dai, Xiao-Yu Zhang},
TITLE = {FOXR2 Promotes the Proliferation, Invasion, and Epithelial–Mesenchymal  Transition in Human Colorectal Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {5},
PAGES = {681--689},
URL = {http://www.techscience.com/or/v25n5/56849},
ISSN = {1555-3906},
ABSTRACT = {Forkhead box R2 (FOXR2), a member of the FOX gene family, has not been very well investigated for its role 
in cancer. A recent study has shown that FOXR2 is highly expressed in breast cancer samples and is associated 
with poor prognosis. In addition, FOXR2 was identified as an oncogene in medulloblastoma. Nevertheless, 
whether FOXR2 plays a role in colorectal cancer (CRC) remains unclear. In the present study, we conducted 
several in vitro and in vivo studies to investigate the expression and effect of FOXR2 in CRC. The study results 
demonstrated that FOXR2 was upregulated in CRC tissues and cells. Downregulation of FOXR2 inhibited 
CRC cell proliferation, invasion, and the epithelial–mesenchymal transition (EMT) phenotype in vitro and 
also suppressed CRC cell growth and metastasis in vivo. Furthermore, downregulation of FOXR2 remarkably 
reduced the protein expression of Shh, Gli1, and Ptch1 in SW480 cells. Taken together, our data suggested that 
FOXR2 significantly promoted proliferation, invasion, and EMT of CRC cells. All these findings provided 
evidence for the role of FOXR2 as an oncogene in CRC development.},
DOI = {10.3727/096504016X14771034190471}
}