@Article{096504016X14774897404770,
AUTHOR = {Zewei Zhang, Chao Xu, Xiafang Zhang, Lulu Huang, Cheng Zheng, Haitao Chen, Yan Wang, Haixing Ju, Qinghua Yao},
TITLE = {TRIM11 Upregulation Contributes to Proliferation, Invasion,  and EMT of Hepatocellular Carcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {5},
PAGES = {691--699},
URL = {http://www.techscience.com/or/v25n5/56850},
ISSN = {1555-3906},
ABSTRACT = {The tripartite motif-containing protein 11 (TRIM11), a member of the TRIM protein family, has attracted 
much attention because of its involvement in the development of the central nervous system. It has gained 
renewed focus because of its newly found function in promoting tumors. However, little is known about its 
role in hepatocellular carcinoma (HCC). In the present study, we found TRIM11 to be overexpressed in HCC 
tissues and cell lines. Downregulation of TRIM11 inhibited HCC cell proliferation and invasion in vitro 
and in vivo as well as suppressed the epithelial–mesenchymal transition (EMT) process. In addition, downregulation of TRIM11 decreased the protein expression levels of p-PI3K and p-Akt in HCC cells and thus 
inhibited activation of the PI3K/Akt signaling pathway. Based on these results, we suggest the importance of 
TRIM11 in HCC progression and the potential of TRIM11 as a therapeutic target for HCC.},
DOI = {10.3727/096504016X14774897404770}
}