TY  - EJOU
AU  - Wang, Yinan 
AU  - Xue, Kai 
AU  - Guan, Yonghong 
AU  - Jin, Yuemei 
AU  - Liu, Shanshan 
AU  - Wang, Yichao 
AU  - Liu, Shuyan 
AU  - Wang, Ling 
AU  - Han, Liying 

TI  - Long Noncoding RNA LINC00261 Suppresses Cell Proliferation and Invasion  and Promotes Cell Apoptosis in Human Choriocarcinoma
T2  - Oncology Research

PY  - 2017
VL  - 25
IS  - 5
SN  - 1555-3906

AB  - Choriocarcinoma is one of the gestational trophoblastic neoplasias (GTNs) that originate in the chorionic villi 
and the extravillous trophoblast. Long noncoding RNAs (lncRNAs) are a type of non-protein-coding RNAs 
that have recently been implicated in human tumorigenesis. The present study investigated the role of the 
lncRNA LINC00261 in cell proliferation, metastasis, and apoptosis in choriocarcinoma cell lines. The transcription level of LINC00261 was significantly lower in choriocarcinoma tissues and in choriocarcinoma cell 
lines. Overexpression of LINC00261 caused a decrease in cell proliferation and arrested the cell cycle at the 
G<sub>0</sub>/G<sub>1</sub> phase. Furthermore, overexpression of LINC00261 inhibited cell migration and invasion. Meanwhile, 
it promoted cell apoptosis and the relative activities of caspase 3 and caspase 9 in choriocarcinoma JEG-3 
and JAR cells. These data suggested that LINC00261 promotes cell proliferation and metastasis in choriocarcinoma. Our data might provide novel insight into the early diagnosis and treatment of choriocarcinoma 
in clinics.
KW  - Choriocarcinoma; LINC00261; Proliferation; Metastasis; Apoptosis

DO  - 10.3727/096504016X14772362173376