@Article{096504016X14772395226335,
AUTHOR = {Dengfeng Zhang, Feng Jiang, Xiao Wang, Guojun Li},
TITLE = {Downregulation of Ubiquitin-Specific Protease 22 Inhibits Proliferation,  Invasion, and Epithelial–Mesenchymal Transition in Osteosarcoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {5},
PAGES = {743--751},
URL = {http://www.techscience.com/or/v25n5/56856},
ISSN = {1555-3906},
ABSTRACT = {Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, belongs to an extended family of 
proteins that have ubiquitin hydrolase activity. Recently, USP22 has attracted widespread attention because 
of its implication in carcinogenesis. However, there have been no studies, to our knowledge, investigating the 
expression of USP22 in osteosarcoma (OS) and its association with OS progression. In this study, we explored 
the role of USP22 in OS. We demonstrated that USP22 was highly expressed in OS tissue and cell lines. 
Downregulation of USP22 inhibited OS cell proliferation, invasion, and epithelial–mesenchymal transition 
(EMT) in vitro. In addition, downregulation of USP22 suppressed OS tumor growth and metastasis in vivo. We 
also found that the PI3K/Akt signaling pathway was involved in the tumor-promoting effect of USP22 on OS 
progression. Taken together, we suggest USP22 as a novel therapeutic target for OS.},
DOI = {10.3727/096504016X14772395226335}
}