@Article{096504016X14759582767486,
AUTHOR = {Sheqing Ji, Bin Zhang, Ye Kong, Fei Ma, Yawei Hua},
TITLE = {miR-326 Inhibits Gastric Cancer Cell Growth  Through Downregulating NOB1},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {6},
PAGES = {853--861},
URL = {http://www.techscience.com/or/v25n6/56867},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs (miRNAs) play a crucial role in the development and progression of human cancers, including 
gastric cancer (GC). The discovery of miRNAs may provide a new and powerful tool for studying the mechanism, diagnosis, and treatment of GC. In this study, we aimed to investigate the role of miR-326 in the development and progression of GC. Quantitative PCR (qPCR) was used to measure the expression level of miR-326 
in GC tissues and cell lines. We found that miR-326 was significantly downregulated during GC. In addition, 
overexpression of miR-326 inhibited GC cell proliferation. Fluorescence-activated cell sorting (FACS) further 
showed that miR-326 significantly induced GC cell G<sub>2</sub>/M arrest. Subsequent dual-luciferase reporter assay 
identified one of the proto-oncogene NOB1 as a direct target of miR-326, and NOB1 can save growth inhibition caused by miR-326. We also confirmed that the growth inhibition caused by miR-326 is associated with 
AKT pathway activation. Taken together, our results indicate that miR-326 could serve as a potential diagnostic 
biomarker and therapeutic option for GC in the near future.},
DOI = {10.3727/096504016X14759582767486}
}