@Article{096504016X14772424117423,
AUTHOR = {Jianping Zhou, Fan Wang, Bingli Liu, Lin Yang, Xueying Wang, Yu Liu},
TITLE = {Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits  the Migration and Tumorigenesis in Glioma Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {6},
PAGES = {931--937},
URL = {http://www.techscience.com/or/v25n6/56875},
ISSN = {1555-3906},
ABSTRACT = {Pediatric glioma is a devastating brain tumor. Serine threonine tyrosine kinase 1 (STYK1) is a member of 
the protein tyrosine kinase family and plays a significant role in the formation of several malignant tumors. 
However, the expression pattern and role of STYK1 in glioma are not yet clear. The aim of this study was to 
investigate the role and molecular mechanism of STYK1 in glioma. The results showed that STYK1 was highly 
expressed in glioma cell lines. We also found that knockdown of STYK1 inhibited cell proliferation, migration, and invasion in vitro as well as tumorigenesis in vivo. Furthermore, knockdown of STYK1 significantly 
decreased the expression levels of phosphorylation of PI3K and Akt in glioma cells. Taken together, our data 
suggest that STYK1 plays an important role in the development and progression of glioma. Therefore, STYK1 
may represent a novel therapeutic target for the treatment of glioma.},
DOI = {10.3727/096504016X14772424117423}
}