@Article{096504016X14803476672380,
AUTHOR = {Fen Liu, Shaojun Liu, Feiyan Ai, Decai Zhang, Zhiming Xiao, Xinmin Nie, Yunfeng Fu},
TITLE = {miR-107 Promotes Proliferation and Inhibits Apoptosis of Colon Cancer Cells  by Targeting Prostate Apoptosis Response-4 (Par4)},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {6},
PAGES = {967--974},
URL = {http://www.techscience.com/or/v25n6/56879},
ISSN = {1555-3906},
ABSTRACT = {Colorectal cancer (CRC) is one of the most common malignancies in the world, with a high incidence and a 
high mortality. However, the pathogenesis of CRC carcinogenesis is still unexplored. In this study, we investigated the role of miR-107 in the regulation of CRC cell proliferation and apoptosis. First, the expression of 
miR-107 was observed to be aberrantly increased in human CRC tumor tissues and cell lines when compared to 
the colonic control tissues and colon epithelial cells. Further study showed that the proliferative and apoptotic 
capacities of human CRC SW480 and LoVo cells were aberrantly regulated by miR-107. The proliferation 
of SW480 and LoVo cells was remarkably enhanced by the miR-107 mimic but suppressed by the miR-107 
inhibitor when compared to the negative control. On the contrary, the apoptotic rate of both SW480 and LoVo 
cells was significantly inhibited by miR-107 overexpression but increased by miR-107 inhibition. In addition, 
we identified prostate apoptosis response-4 (Par4) as a direct target of miR-107 with a potential binding site 
on the 3'-UTR of mRNA, as evaluated by bioinformatics prediction and luciferase reporter assay. Par4 expression levels were significantly inhibited by the miR-107 mimic but upregulated by the miR-107 inhibitor in 
both SW480 and LoVo cells. Compared to the control, the increase in Par4 expression significantly inhibited 
the induction role of miR-107 in the proliferation of SW480 and LoVo cells, and the apoptotic rate of cells 
repressed by the miR-107 mimic was also reversed by Par4 overexpression. In summary, our results demonstrated that miR-107 exerts a positive role in the survival of CRC cells by directly targeting Par4. This might 
reveal a novel understanding about human CRC pathogenesis.},
DOI = {10.3727/096504016X14803476672380}
}