@Article{096504016X14813859905646,
AUTHOR = {Zhenfeng Jiang, Lifen Yao, Hongge Ma, Panpan Xu, Zhiyan Li, Mian Guo, Jianhang Chen, Hongbo Bao, Shupei Qiao, Yufang Zhao, Jia Shen, Minwei Zhu, Carolyn Meyers, Guizhen Ma, 
Chuncheng Xie, Li Liu, Haiyang Wang, Wang Zhang, Qi Dong, Hong Shen, Zhiguo Lin},
TITLE = {miRNA-214 Inhibits Cellular Proliferation and Migration in Glioma Cells  Targeting Caspase 1 Involved in Pyroptosis},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {6},
PAGES = {1009--1019},
URL = {http://www.techscience.com/or/v25n6/56883},
ISSN = {1555-3906},
ABSTRACT = {Pyroptosis is a type of proinflammatory programmed cell death mediated by caspase 1 activity and occurs in 
several types of eukaryotic tumor cells, including gliomas. MicroRNAs (miRNAs), small endogenous noncoding RNAs, have been demonstrated to be advantageous in glioma therapy. However, the question of whether 
miRNAs regulate pyroptosis in glioma remains unknown. The current study found that caspase 1 expression was substantially increased in both glioma tissues and glioma cell lines, U87 and T98G, while miR-214 
expression was significantly downregulated. Luciferase reporter assay recognized caspase 1 as a target gene of 
miR-214. These findings demonstrate that miR-214 could inhibit cell proliferation and migration through the 
regulation of pyroptosis intermediated by caspase 1 in glioma U87 and T98G cells and may suggest a novel 
therapeutic for the intervention of glioma.},
DOI = {10.3727/096504016X14813859905646}
}