@Article{096504016X14813914187138,
AUTHOR = {Hai-tao Geng, Rui-juan Cao, Lei Cheng, Chun-yuan Liu},
TITLE = {Overexpression of Hepatocyte Cell Adhesion Molecule (hepaCAM) Inhibits  the Proliferation, Migration, and Invasion in Colorectal Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {7},
PAGES = {1039--1046},
URL = {http://www.techscience.com/or/v25n7/56886},
ISSN = {1555-3906},
ABSTRACT = {Hepatocyte cell adhesion molecule (hepaCAM), a new type of CAM, belongs to the immunoglobulin superfamily. Recently, hepaCAM was reported to be implicated in cancer development, and many researchers 
investigated its biological function in the tumorigenesis of various cancers. However, what kind of role 
hepaCAM plays in colorectal cancer (CRC) remains unknown. In this study, we found that hepaCAM was 
downregulated in CRC tissues and cell lines. Overexpression of hepaCAM inhibited CRC cell proliferation, 
migration, and invasion in vitro. Furthermore, the tumorigenesis assay showed that increased expression of 
hepaCAM suppressed CRC tumor growth and metastasis in vivo. We also demonstrated that overexpression 
of hepaCAM reduced the protein expression levels of β-catenin, cyclin D1, and c-Myc, indicating its inhibitory effect on the Wnt/β-catenin signaling pathway. In conclusion, our study results suggest hepaCAM as 
a promising therapeutic target for CRC and provide a better understanding for the molecular basis of CRC 
progression.},
DOI = {10.3727/096504016X14813914187138}
}