@Article{096504016X14829256525028,
AUTHOR = {Yueli Gu, Jinchun Si, Xichun Xiao, Ying Tian, Shuo Yang},
TITLE = {miR-92a Inhibits Proliferation and Induces Apoptosis by Regulating  Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2)  Expression in Acute Myeloid Leukemia},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {7},
PAGES = {1069--1079},
URL = {http://www.techscience.com/or/v25n7/56889},
ISSN = {1555-3906},
ABSTRACT = {Aberrant expression of microRNA-92a (miR-92a) has been investigated in various cancers. However, the function and mechanism of miR-92a in acute myeloid leukemia (AML) remain to be elucidated. Our data showed 
that miR-92a was evidently downregulated and methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) was 
remarkably upregulated in AML cell lines HL-60 and THP-1. Dual luciferase reporter assay revealed that 
MTHFD2 was a direct target of miR-92a. Gain- and loss-of-function analysis demonstrated that MTHFD2 
knockdown or miR-92a overexpression notably inhibited proliferation and promoted apoptosis of AML cell 
lines. Restoration of MTHFD2 expression reversed proliferation inhibition and apoptosis induction of AML 
cells triggered by miR-92a. Moreover, an implanted tumor model in mice indicated that miR-92a overexpression dramatically decreased tumor growth and MTHFD2 expression in vivo. Taken together, our results suggest 
that miR-92a inhibits proliferation and induces apoptosis by directly regulating MTHFD2 expression in AML. 
miR-92a may act as a tumor suppressor in AML, providing a promising therapeutic target for AML patients.},
DOI = {10.3727/096504016X14829256525028}
}