@Article{096504016X14784668796788,
AUTHOR = {Lei Yang, Fei Xie, Shuangqing Li},
TITLE = {Downregulation of Homeobox B7 Inhibits the Tumorigenesis  and Progression of Osteosarcoma},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {7},
PAGES = {1089--1095},
URL = {http://www.techscience.com/or/v25n7/56891},
ISSN = {1555-3906},
ABSTRACT = {Homeobox B7 (HOXB7), a member of the HOX gene family, plays a role in tumorigenesis. However, until 
now the expression status and role of HOXB7 in osteosarcoma remain unclear. Therefore, the present study 
aimed to investigate the functional role and mechanism of HOXB7 in osteosarcoma. Our results demonstrated 
that HOXB7 was overexpressed in osteosarcoma cell lines. Downregulation of HOXB7 significantly inhibited 
osteosarcoma cell proliferation in vitro, as well as attenuated xenograft tumor growth in vivo. Downregulation 
of HOXB7 also inhibited the migration and invasion of osteosarcoma cells. Furthermore, downregulation 
of HOXB7 significantly suppressed the protein expression levels of p-PI3K and p-Akt in U2OS cells. In 
summary, our data demonstrated that downregulation of HOXB7 inhibited proliferation, invasion, and tumorigenesis, partly through suppressing the PI3K/Akt signaling pathway in osteosarcoma cells. Our findings 
provide new insights into the role of HOXB7 in osteosarcoma and new therapeutic targets for the treatment 
of osteosarcoma.},
DOI = {10.3727/096504016X14784668796788}
}