@Article{096504017X14836170586829,
AUTHOR = {Yidong Cao, Liang Zhang, Minghao Wei, Xue Jiang, Dong Jia},
TITLE = {MicroRNA-409-3p Represses Glioma Cell Invasion and Proliferation  by Targeting High-Mobility Group Nucleosome-Binding Domain 5},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {7},
PAGES = {1097--1107},
URL = {http://www.techscience.com/or/v25n7/56892},
ISSN = {1555-3906},
ABSTRACT = {Emerging evidence has suggested that aberrantly expressed microRNAs (miRNAs) are associated with glioma 
development and progression. The aberrant expression of miR-409-3p has been reported in several human cancers. However, little is known about the function of miR-409-3p in gliomas. The aim of this study was to investigate the specific role and molecular mechanism of miR-409-3p in gliomas. In the present study, we found 
that miR-409-3p was downregulated in glioma tissue and cell lines. Overexpression of miR-409-3p inhibited 
glioma cell invasion and proliferation, whereas suppression of miR-409-3p promoted glioma cell invasion 
and proliferation. High-mobility group nucleosome-binding domain 5 (HMGN5), a well-known oncogene in 
gliomas, was identified as a functional target of miR-409-3p using bioinformatics, dual-luciferase reporter 
assay, real-time quantitative polymerase chain reaction, and Western blot analysis. Furthermore, miR-409-3p 
was found to regulate the expression of matrix metalloproteinase 2 and cyclin D1. Restoration of HMGN5 
expression significantly reversed the inhibitory effects of miR-409-3p overexpression on glioma cell invasion 
and proliferation. Taken together, our results suggest that miR-409-3p inhibits glioma cell invasion and proliferation by targeting HMGN5, representing a potential therapeutic target for glioma.},
DOI = {10.3727/096504017X14836170586829}
}