@Article{096504016X14800889609439,
AUTHOR = {Yan Zhen, Jia Liu, Yujie Huang, Yajun Wang, Wen Li, Jun Wu},
TITLE = {miR-133b Inhibits Cell Growth, Migration, and Invasion by Targeting  MMP9 in Non-Small Cell Lung Cancer},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {7},
PAGES = {1109--1116},
URL = {http://www.techscience.com/or/v25n7/56893},
ISSN = {1555-3906},
ABSTRACT = {Although increasing evidence indicates that the deregulation of microRNAs (miRNAs) contributes to tumorigenesis and invasion, little is known about the role of miR-133b in human non-small cell lung cancer (NSCLC). 
In the present study, we revealed that the introduction of miR-133b dramatically suppressed NSCLC cell 
growth, migration, and invasion in vitro. On the contrary, miR-133b inhibitors promoted cell growth, migration, and invasion in vitro. Further studies revealed that matrix metallopeptidase 9 (MMP9) is a direct target 
gene of miR-133b. Silencing MMP9 inhibited cell growth, migration, and invasion of NSCLC cells, which 
was consistent with the effect of miR-133b overexpression. In clinical specimens, reduced miR-133b was an 
unfavorable factor and negatively correlated with MMP9 expression. Our studies demonstrate that miR-133b 
inhibits cell growth, migration, and invasion by targeting MMP9 in NSCLC.},
DOI = {10.3727/096504016X14800889609439}
}