@Article{096504017X14865126670075,
AUTHOR = {Jie Guo, Jinqi Ma, Guosheng Zhao, Guocai Li, Yunfeng Fu, Yanwei Luo, Rong Gui},
TITLE = {Long Noncoding RNA LINC0086 Functions as a Tumor Suppressor  in Nasopharyngeal Carcinoma by Targeting miR-214},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {7},
PAGES = {1189--1197},
URL = {http://www.techscience.com/or/v25n7/56903},
ISSN = {1555-3906},
ABSTRACT = {Nasopharyngeal carcinoma (NPC) is a distinct head and neck cancer, which is occurring at a high frequency 
in Southern China. Emerging studies have shown that long noncoding RNAs (lncRNAs) play a critical role 
in carcinogenesis and progression. In this study, we established a comprehensive lncRNA profile in NPC 
and found that 35 lncRNAs were differentially expressed in NPC. We found that LINC0086 was decreased 
in NPC patient serum samples and tissues. The Kaplan–Meier survival curve showed that patients with high 
LINC0086 expression had a higher survival rate than those with low LINC0086 expression. LINC0086 expression was associated with NPC histological grade, lymph node metastasis, and clinical stage. Upregulation of 
LINC0086 inhibited cancer cell proliferation and promoted apoptosis. In addition, upregulation of LINC0086 
dramatically decreased the expression of miR-214, an oncogene in several cancers, in C666-1 and HK-1 cells. 
An miR-214 binding site was found in the 3'-UTR of LINC0086. We also validated that both miR-214 and 
LINC0086 presented in the RISC complex, demonstrating that LINC0086 could decrease miR-214 expression 
by directly interacting with miR-214. Furthermore, the suppressive effects of LINC0086 on NPC cell growth 
were reversed by overexpression of miR-214 in vitro and in vivo. Thus, our study reports a novel mechanism 
underlying NPC carcinogenesis and provides a potential novel diagnosis and treatment biomarker for NPC.},
DOI = {10.3727/096504017X14865126670075}
}