@Article{096504017X14873444858101,
AUTHOR = {Peihe Wang, Yuanyuan Cai, Dongju Lin, Yingxiao Jiang},
TITLE = {Gamma Irradiation Upregulates B-cell Translocation Gene 2  to Attenuate Cell Proliferation of Lung Cancer Cells  Through the JNK and NF-κB Pathways},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {7},
PAGES = {1199--1205},
URL = {http://www.techscience.com/or/v25n7/56904},
ISSN = {1555-3906},
ABSTRACT = {Gamma ray can promote cancer cell apoptosis and cell cycle arrest. It is often used in the clinical treatment of 
tumors, including lung cancer. In this study, we aimed to explore the role of gamma ray treatment and its correlation with BTG2 in cell proliferation, apoptosis, and cell cycle arrest regulation in a lung cancer cell line. 
A549 cell viability, apoptosis rate, and cell cycle were investigated after gamma ray treatment. We then used 
siRNA for BTG2 to detect the effect of BTG2 knockdown on the progress of gamma ray-treated lung cancer 
cells. Finally, we investigated the signaling pathway by which gamma ray might regulate BTG2. We found that 
gamma ray inhibited A549 cell viability and promoted apoptosis and cell cycle arrest, while BTG2 knockdown 
could relieve the effect caused by gamma ray on A549 cells. Moreover, we confirmed that the effect of BTG2 
partly depends on p53 expression and gamma ray-promoting BTG2 expression through the JNK/NF-kB signaling pathway. Our study assessed the possible mechanism of gamma ray in tumor treatment and also investigated the role of BTG2 in gamma ray therapy. All these findings might give a deep understanding of the effect 
of gamma ray on the progression of lung cancer involving BTG2.},
DOI = {10.3727/096504017X14873444858101}
}