@Article{096504017X14854310794561,
AUTHOR = {Yuying Tan, Hanxin Yao, Jinghai Hu, Lingyun Liu},
TITLE = {Knockdown of TRIM44 Inhibits the Proliferation and Invasion  in Prostate Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {8},
PAGES = {1253--1259},
URL = {http://www.techscience.com/or/v25n8/56910},
ISSN = {1555-3906},
ABSTRACT = {Tripartite motif 44 (TRIM44), a member of the TRIM protein family, has been shown to play a role in tumor 
development and progression. However, the potential involvement of TRIM44 in prostate cancer has not been 
fully explored. Therefore, in the present study, we analyzed the expression of TRIM44 in prostate cancer and 
assessed the role of TRIM44 in the progression of prostate cancer. Our results showed that the expression of 
TRIM44 was significantly upregulated in human prostate cancer cell lines. In addition, knockdown of TRIM44 
significantly inhibited the proliferation, migration, and invasion of prostate cancer cells in vitro, as well as 
attenuated the tumor growth in vivo. Mechanistic studies showed that knockdown of TRIM44 significantly 
reduced the levels of phosphorylated PI3K and Akt in PC-3 cells. In conclusion, this study provided evidence 
that knockdown of TRIM44 inhibited proliferation and invasion in prostate cancer cells, at least in part, through 
the inactivation of the PI3K/Akt signaling pathway. These results suggest that TRIM44 may be a potential 
therapeutic target for the treatment of prostate cancer.},
DOI = {10.3727/096504017X14854310794561}
}