@Article{096504017X14881559833562,
AUTHOR = {Ya-Li Gao, Zi-Shen Zhao, Ming-Yun Zhang, Li-Jie Han, Yu-Jin Dong, Bo Xu},
TITLE = {Long Noncoding RNA PVT1 Facilitates Cervical Cancer Progression  via Negative Regulating of miR-424},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {8},
PAGES = {1391--1398},
URL = {http://www.techscience.com/or/v25n8/56924},
ISSN = {1555-3906},
ABSTRACT = {Emerging evidence suggests that the long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 
(PVT1) gene is involved in the pathogenesis of cervical cancer. However, the potential mechanism is rarely 
reported. Our study found that PVT1 was upregulated in cervical cancer tissue and cell lines. After transfecting PVT1 siRNA, the proliferation, migration, and invasion of cervical cancer cells were markedly decreased. 
miRNA expression profiles demonstrate that miR-424 was markedly downregulated in cervical cancer tissue. 
Bioinformatics analysis revealed that miR-424 was potentially targeted by PVT1, which was confirmed by 
dual-luciferase reporter assay. Pearson’s correlation analysis showed that PVT1 expression was negatively 
related to miR-424 expression in glioma cancer tissues. Finally, lowered expression of miR-424 could recover 
the tumor-suppressive effects of PVT1 knockdown in cervical cancer cell lines. Our results reveal a tumorpromoting role for PVT1, acting as a competing endogenous RNA (ceRNA) or a molecular sponge in negatively modulating miR-424, which might provide a novel therapeutic target for cervical cancer.},
DOI = {10.3727/096504017X14881559833562}
}