@Article{096504017X14886485417426,
AUTHOR = {Shaokun Zhang, Lidi Liu, Zhenshan Lv, Qiao Li, Weiquan Gong, Hong Wu},
TITLE = {MicroRNA-342-3p Inhibits the Proliferation, Migration, and Invasion of  Osteosarcoma Cells by Targeting Astrocyte-Elevated Gene-1 (AEG-1)},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {9},
PAGES = {1505--1515},
URL = {http://www.techscience.com/or/v25n9/56936},
ISSN = {1555-3906},
ABSTRACT = {Recent studies suggest that microRNAs (miRNAs) are critical regulators in many types of cancer, including 
osteosarcoma. miR-342-3p has emerged as an important cancer-related miRNA in several types of cancers. 
However, the functional significance of miR-342-3p in osteosarcoma is unknown. The aims of this study were 
to investigate whether miR-342-3p is dysregulated in osteosarcoma and to explore the biological function of 
miR-342-3p in regulating cellular processes of osteosarcoma cells. We found that miR-342-3p expression was 
significantly decreased in osteosarcoma tissues and cell lines. Overexpression of miR-342-3p inhibits the proliferation, migration, and invasion of osteosarcoma cells. In contrast, the inhibition of miR-342-3p exhibited the 
opposite effect. Astrocyte-elevated gene-1 (AEG-1) was identified as one of the target genes of miR-342-3p in 
osteosarcoma cells by bioinformatics analysis, dual-luciferase reporter assay, real-time quantitative polymerase 
chain reaction, and Western blot analysis. Overexpression of miR-342-3p also inhibited the Wnt and nuclear 
factor kB signaling pathways. Moreover, overexpression of AEG-1 partially rescued the inhibitory effects of 
miR-342-3p mediated on the proliferation, migration, and invasion of osteosarcoma cells. Overall, our results 
show that miR-342-3p inhibits the proliferation, migration, and invasion of osteosarcoma cells through targeting AEG-1, suggesting a potential target for the development of miRNA-based therapy for osteosarcoma.},
DOI = {10.3727/096504017X14886485417426}
}