@Article{096504017X14859934460780,
AUTHOR = {Juntao Wang, Guodong Sun},
TITLE = {FOXO1–MALAT1–miR-26a-5p Feedback Loop Mediates Proliferation  and Migration in Osteosarcoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {9},
PAGES = {1517--1527},
URL = {http://www.techscience.com/or/v25n9/56937},
ISSN = {1555-3906},
ABSTRACT = {miR-26a has been found to be downregulated in osteosarcoma (OS) when compared with normal control 
tissues and has been shown to suppress the malignant behaviors of OS cells. The underlying mechanism, 
nevertheless, remains unknown. In our study, the long noncoding RNA MALAT1, confirmed to be significantly 
upregulated in OS, is first shown to be capable of promoting proliferation and migration by directly suppressing miR-26a-5p in OS cells. In addition, we have identified forkhead box O1 (FOXO1) as a transcriptional 
factor of MALAT1 that can negatively regulate MALAT1. We have shown that MALAT1 promoted growth 
and migration through inhibiting miR-26a-5p in OS cells. Suppression of FOXO1, identified as a regulatory 
transcriptional factor of MALAT1, was shown to be able to slow down both proliferation and metastases in OS 
cells, suggesting that targeting FOXO1 can be useful in the therapy of patients with OS.},
DOI = {10.3727/096504017X14859934460780}
}