@Article{096504017X14908284471361,
AUTHOR = {Liyun Shen, Xingjun Du, Hongyan Ma, Shunxi Mei},
TITLE = {miR-1193 Suppresses the Proliferation and Invasion of Human T-Cell  Leukemia Cells Through Directly Targeting the Transmembrane 9  Superfamily 3 (TM9SF3)},
JOURNAL = {Oncology Research},
VOLUME = {25},
YEAR = {2017},
NUMBER = {9},
PAGES = {1643--1651},
URL = {http://www.techscience.com/or/v25n9/56949},
ISSN = {1555-3906},
ABSTRACT = {miRNAs have been involved in various types of cancer, including T-cell leukemia. In this study, the role of 
miR-1193 in the proliferation and invasion of T-cell leukemia cells was explored. First, we found that miR-1193 
was sharply downregulated in T-cell leukemia cells when compared with normal T cells. miR-1193 markedly 
decreased the proliferation and invasion in Jurkat human T-cell leukemia cells. Transmembrane 9 superfamily 3 (TM9SF3) was then predicted to be a potential target gene of miR-1193, the levels of which displayed a 
strongly negative correlation with miR-1193 levels in T-cell leukemia patients. We confirmed that TM9SF3 
was a target gene of miR-1193 by luciferase reporter gene assay. Finally, gene overexpression and knockdown 
experiments in Jurkat cells revealed that TM9SF3 positively regulated cell proliferation and invasion.},
DOI = {10.3727/096504017X14908284471361}
}