@Article{096504016X14772410356982,
AUTHOR = {Yingchao Li, Xiaoni Yan, Li Ren, Yang Li},
TITLE = {miR-644a Inhibits Cellular Proliferation and Invasion  via Suppression of CtBP1 in Gastric Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {1},
PAGES = {1--8},
URL = {http://www.techscience.com/or/v26n1/56612},
ISSN = {1555-3906},
ABSTRACT = {Epithelial–mesenchymal transition (EMT) is one of the most important mechanisms in the metastasis of various cancers, including gastric cancer (GC). In this study, we explored the putative significance of miR-644a 
and its role in EMT-mediated metastasis of GC. We first detected the expression of miR-644a in a cohort of 
107 GC tissues using quantitative RT-PCR. The expression of miR-644a was suppressed in GC tissues and was 
associated with a later clinical stage and tumor metastasis. Restoring the expression of miR-644a could significantly suppress the migration and invasion of HGC-27 and SGC-7901 cells, which might be correlated to its 
suppressive effect on the EMT process. We also found that carboxyl-terminal-binding protein 1 (CtBP1) was a 
putative target gene of miR-644a in GC and might be involved in the suppressive effect. Collectively, through 
targeting CtBP1-mediated suppression of the EMT process, miR-644a might suppress the tumor metastasis of 
GC cells.},
DOI = {10.3727/096504016X14772410356982}
}