@Article{096504017X14900515946914,
AUTHOR = {Ling Li, He-Sheng Luo},
TITLE = {G-Protein Signaling Protein-17 (RGS17) Is Upregulated and Promotes  Tumor Growth and Migration in Human Colorectal Carcinoma},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {1},
PAGES = {27--35},
URL = {http://www.techscience.com/or/v26n1/56615},
ISSN = {1555-3906},
ABSTRACT = {Colorectal carcinoma is one of the leading causes of cancer-related deaths and has a high tendency for metastasis, which makes it a priority to find novel methods to diagnose and treat colorectal carcinoma at a very early 
stage. We studied the role of the regulator of G-protein signaling (RGS) family of proteins RGS17 in colorectal 
carcinoma growth and metastasis. We found that RGS17 was upregulated in both clinical colorectal carcinoma 
tissues and cultured colorectal carcinoma cells. Knockdown of RGS17 by specific siRNA decreased the cell 
proliferation rate, whereas overexpression of RGS17 with expression plasmid increased the rate in cultured 
cells. Consistently, a mouse model for colorectal carcinoma also showed that depletion of RGS17 significantly 
inhibited tumor growth in vivo. Moreover, a Transwell assay showed that RGS17 promoted the ability of colorectal carcinoma cells to migrate and invade. These data suggest that RGS17 is overexpressed in colorectal 
carcinoma and promotes cell proliferation, migration, and invasion.},
DOI = {10.3727/096504017X14900515946914}
}